Leukoegresin: A Factor from Rabbit Skin Associated with Leucocytic Emigration in the Arthus Reaction

摘要

Permeability factors were isolated from the Arthus skin lesion during the period of increased vascular permeability change. Promoters of leucocyte emigration were found in leucocytes or tissue-serum mixtures and lymph node cells, but these substances have not yet been purified satisfactorily. The cationic protein from polymorphonuclear (PMN) lysosomes, and leucotaxine from pleural exudates stimulate PMN emigration, but they also increase vascular permeability. This communication deals with isolation and purification of a factor which is associated with leucocyte emigration in Arthus lesions. (Author)