Catabolic Phase of Hemin Chromoprotein Metabolism

摘要

A brief summary is given of work which involved the following specific investigations: Level of output of bile pigment; Potential of hemoglobin breakdown to bile pigment; Role of haptoglobin; Breakdown of injected myoglobin, cytochrome c, denatured hemoglobin, and hematin solutions of pH 8.5 to bile pigment; Role of the liver in hemin chromoprotein breakdown; Reticuloendothelial system; Liver perfusion experiments; The hemophagous organ; A new cell-free enzyme system, prepared from the hemophagous organ and capable of degrading hemin and hemoglobin to biliverdin; and Production of carbon monoxide in the process of bile pigment production from hemin and hemoglobin.