Improving Microcirculation with Therapeutic Intrathoracic Pressure Regulation in a Porcine Model of Hemorrhage.

摘要

Aim of study: Intrathoracic pressure regulation (IPR) has been used to treat hypotension and states of hypoperfusion by providing positive pressure ventilation during inspiration followed by augmentation of negative intrathoracic pressure during expiration. This therapy augments cardiac output and lowers intracranial pressure, thereby providing greater circulation to the heart and brain. The effects of IPR on microcirculation remain unknown. Methods: Using a hemorrhagic model, hemodynamics and sublingual microcirculation were evaluated after a 55% blood loss over a 30 min timeframe in 10 female farm pigs (30 kg) previously anesthetized with isoflurane. Results: After hemorrhage the mean arterial pressure was 27 4mmHg. Blood cell velocity, the key indicator of microcirculation, was significantly reduced after the bleed from 1033 175 m/s pre-bleed to 147 60 m/s (p < 0.0001). Application of an IPR device reduced airway pressure during expiration to 9 mm Hg after each positive pressure breath (10 mL/kg, 10 breaths/min) and resulted in a rapid increase in systemic hemodynamics and microcirculation. During IPR treatment, average mean arterial pressure increased by 59% to 43 6mmHg (p = 0.002) and blood cell velocity increased by 344% to 506 99 m/s (p = 0.001). Conclusion: In this animal model, we observed that microcirculation and systemic blood pressures are correlated and may be significantly improved by using IPR therapy.