Regulation of Lipid Transport and Deposition: Effects of Nicotonic Acid

摘要

The effects of nicotinic acid on lipid transport were studied in two series of experiments. In the first, nicotinic acid was administered to normal and adreno-demedullated rats exposed to cold. Results showed that nicotinic acid specifically blocked free fatty acid mobilization during cold exposure without altering glucose mobilization. In the second series of experiments, measurements were made of the incorporation of C 14 into triglyceride by epididymal fat pads using C 14-glucose as substrate. Results showed that nicotinic acid did not increase utilization of glucose for triglyceride synthesis in fat pads from fed rats except when norepinephrine was present. In fat pads from fasted rats, nicotinic acid increased incorporation of C 14 from glucose into triglyceride, but epinephrine decreased that incorporation. These facts are discussed in relation to the interrelationships of hormones, glucose, and nicotinic acid on fat synthesis and mobilization from peripheral tissues. (Author)