Renal and Hematologic Complications of Acute Falciparum Malaria in Vietnam.

摘要

Hematologic complications of malaria or malaria therapy include decreased circulating platelets, erythrocytes, and leukocytes. Thrombocytopenia is seen in association with consumptive coagulopathy or rarely in association with drug therapy. Severe hemolysis, although generally related to intense parasitemia, may be associated with specific red cell enzyme defects or with the administration of quinine. The usual patient with hemolysis secondary to malaria infections has a delayed erythropoietic response until parasitemia has been eradicated. Pyrimethamine probably does not contribute to the delayed response unless anemia is severe. Leukopenia is common during the firest few days of an acute attack of malaria, but the count of white blood cells approaches normal with therapy. A decrease in circulating leukocytes to levels less than 3000/cu mm during therapy may represent an idiosyncratic reaction. (Author)