Hemolytic Effects of Single and Multiple Dosages of Antimalarial Drugs in G6PD Deficient Sardinians.

摘要

Clinical studies with single or multiple doses of primaquine administered to glucose-6-phosphate dehydrogenase (G6PD) deficient Sardinians induce a non strictly dose dependent hemolysis, the severity of which showed marked individual variation. For the same individual, however, a reproducible hemolytic response was obtained when the drug was administered daily. The hemolytic episodes though self-limited in nature were sometimes severe, thus making a widespread use of primaquine (in the usual doses) unadvisable for G6PD deficient Sardinians. In G6PD deficient Sardinian males diaminodiphenylsulfone (DDS) is moderately hemolytic and at low doses less hemolytic than equally low doses of primaquine. The study of the combined effects of daily doses of DDS and a single dose of 45 mg of primaquine on G6PD deficient erythrocytes transfused into normal volunteers, indicate that as far as a hemolysis is concerned the two drugs may act synergistically. (Author)