Early Effects of Hemorrhagic Shock on Surface Tension Properties and Ultrastructure of Canine Lungs

摘要

No significant decrease in pulmonary surfactant was observed within 24 hours in dogs following a three to four hour period of hemorrhagic shock in contrast to other published reports. Although pulmonary changes observed on light and electron microscopy correlate well with each other and include extensive alveolar type II cell damage within the time period, there is no correlation with surfactant levels. Since the turnover rate for surfactant is 18 to 24 hours, however, the damaged alveolar type II cells cannot replenish surfactant which serves to explain absence of surfact activity in late survivors of shock. There was no evidence of capillary damage nor intravascular coagulation suggesting that pulmonary hypoperfusion alone can produce the cellular damage of the post-hemorrhagic shock lung. (Author)