High Serum 25-hydroxyvitamin D is Associated with Low Incidence of Stress Fractures.

摘要

Low serum 25-hydroxyvitamin D 25(OH)D levels cause rickets and osteomalacia, but it is unknown whether the condition increases risk of stress fractures in young adult. This study was conducted to determine if young women with low serum 25(OH)D have an increased risk of stress fracture compared to those at higher levels. Methods. The Department of Defense has collected and frozen serum from over nine million service members. Pre-fracture serum specimens from 600 female cases of stress fracture of the tibia or fibula that occurred during the first 180 days of active-duty were analyzed for 25(OH)D content. Specimens from 600 controls, individually matched to the cases on age (+/-2 years);race (white, black or other); length of service +/- 30 days; who had blood drawn within 2 days of the case; and were on active duty within 30 days of the case's diagnosis also were analyzed.