Effects of Decaborane on Liver Glycogen Content of Rats at Ground Level and at Altitude

摘要

The effect of decaborane (15 mg./kg.) on the hepatic glycogen of male rats maintained at altitude (18,000 ft.) under normoxic conditions was compared with the effect on similarly injected, ground level controls. Results showed that decaborane decreased the glycogen level of fed rats at ground level, but did not affect glycogen levels in the fed, altitude group. The hepatic glycogen level of fasted rats at altitude was the equivalent of that of fasted rats at ground level. These results indicate that the mechanism whereby decaborane produces a depletion of liver glycogen is altered under conditions of reduced pressure. (Author)