Evaluation of Molecular Weight from Equilibrium Sedimentation. Part Iii. Molecular Weight Distributions from Equilibrium Sedimentation-Diffusion Data Via Linear Programming

摘要

Within the past decade easy access to high speed digital computers has renewed interest in deriving a molecular weight distribution from equilibrium sedimentation-diffusion data. One of the computational schemes which appears most promising is the Simplex Method of linear programming. The purpose of the work was to investigate the advantages and limitations of this approach. It was found that even though inferring a molecular weight distribution from equilibrium sedimentation-diffusion data is mathematically an ill-posed problem, the method of linear programming yields qualitatively a good molecular weight distribution. Also, the method is applicable to the case of one angular velocity. (Author)