Tissue Transplantation: The Universal Donor and Blood Group Antibodies

摘要

Compatibility problems encountered in selecting the group O universal blood donor are reviewed and considered with other antigenic factors that could influence the immunological success of organ transplant. Varous vaccines and parenterals were assayed for A and B blood group substance. The effects of those injectables containing A and/or B substance and used in immunization programs with group O universal donors were studied. The observations by various workers that 15-30% of patients requiring renal transplantation have detectable lymphocytotoxic antibodies at the time of transplantation have resulted in a plea for avoidance of sensitization of the HL-A antigens. Consideration is given to reports that A and B antigens play a significant role in graft rejection and, in this respect, to the problem posed by the group O universal donor who receives vaccination products containing A and/or B substance. (Author)