Evaluation of Antimotion Sickness Drugs: A New Effective Remedy Revealed

摘要

Three single drugs (one used in three dosage levels) and three drug combinations were compared in their effectiveness to prevent motion sickness under standarized stress conditions in a slow rotation room. An unexpected finding was that a combination of promethazine 25 mg with d-amphetamine 10 mg had the same range of effectiveness as that found in earlier studies (and confirmed here) for scopolamine 0.6 mg plus d-amphetamine 10 mg. When scopolamine was tested alone, halving the 'usual' dose (0.6 mg) reduced its effectiveness about one-fifth and doubling the usual dose increased effectiveness by 29 per cent; thus, the optimum dose of scopolamine appeared to be approximately 0.5 mg. Betahistine hydrochloride (4 mg) was ineffective and cinnarizine (50 mg) was of small benefit. (Author)