Interaction of Chlorpromazine and Tissue Binding Sites: Preliminary Studies

摘要

Minced tissue from various body components of rat were subjected to equilibrium dialysis after incubation with chlorpromazine (CPZ). Radioactive CPZ (35S-labeled) was used as a tracer. Tissue binding at low concentrations (0.8 to 3.4 micrograms/ml.) and higher concentrations (0.2 to 4 mg/ml.) demonstrated binding averages. At the higher incubation concentrations, a decrease in slope estimates indicated probable secondary binding sites. (Author)