Alpha Globulins in Those Susceptible to Viral Acute Respiratory Diseases.

摘要

The respiratory disease pattern observed in two companies of naval recruits during a 1959-1960 (Fall-Winter and Summer) epidemiological survey indicated an average of more than 2discrete respiratory episodes per man. Over 50% demonstrated antibody responses to multiple antigens,while only 15.6% failed to show a serological rise to a viral respiratory antigen. Most of the infections were acquired during the first half of the training period. There were 2distinct peaks of clinical disease. The first occurred the 10th day of training,and the second on the 25th day. The peaks of clinical disease were followed on both instances by serological peaks 10days later. The alpha-1globulin values were found to be significantly elevated in 40% of the recruits who subsequently demonstrated multiple serological responses. Seventy-five percent of the recruits considered to be susceptibles on the basis of demonstrating more than 2discrete respiratory episodes had significantly elevated initial serum alpha-1globulin levels. A highly significant relationship (p = <0.001) was found between number of discrete episodes and the alpha-1globulin levels. (Author)