Relative Toxicity of Candidate Mothproofing Uniform Impregnant Didecyl Dimethyl Ammonium Chloride Aliquat 203Trade Mark.

摘要

The relative toxicity of a candidate uniform mothproofing impregnant didecyl dimethyl ammonium chloride (Aliquat 203) was investigated using mice,rats,guinea pigs,rabbits and humans. The technical grade compound and aqueous solutions of 0.1percent or greater caused primary skin irritation in rabbits. No primary skin or eye irritation in rabbits resulted from a single 24hour application of a 0.01percent aqueous solution. The skin irritating properties of Aliquat 203in guinea pigs prevented the determination of the sensitization potential of this compound. Chronic ingestion of 800ppm Aliquat 203for 90days caused minimal changes in rats. Cloth impregnated with 0.5percent (w/w) Aliquat 203and applied continuously to the shaved skin of rabbits for 90days produced no remarkable degree of skin irritation or evidence of potential toxicologic hazard. A prophetic patch test in humans or Aliquat 203impregnated in wool fabric at a concentration of 0.5percent by weight produced no evidence of skin irritation or sensitization. No data were developed which indicated that it would be hazardous to wear uniforms,for short periods of time,impregnated with 0.5percent (w/w) Aliquat 203. (Author)