Effects of Hydrazine on Electrophysiology, Behavior and Runway Performance in the Cat

摘要

The effects of intraperitoneally administered hydrazine on electrophysiology, general behavior and integrated performance in cats was evaluated in a number of independent studies. Doses of 15 to 20 mg/kg hydrazine resulted in death 2 to 24 hours after administration, preceded by overt emesis, salivation, panting and hyperactivity. Doses of 5 to 10 mg/kg produced emesis, hyperactivity and loss of appetite resulting in extensive weight loss. Exposure to 2 to 4 mg/kg produced lethargy and mild weight loss only. In runway performance tests, 1.5 mg/kg produced no significant alterations on the day of administration, but completely disrupted performance within 48 hours. A dose of 0.75 mg/kg hydrazine had no effects on the day of administration, but disrupted or altered performance were observed following a dose of 0.375 mg/kg hydrazine. Very low dose exposure to hydrazine can significantly alter performance capability without producing overt behavioral or physiological symptoms. (Author)