Methods for the Characterization and Study of the Inheritance of Red Cell Antigens in 'Macaca irus' Monkeys

摘要

High or low titer red cell antibodies were produced by all the isoimmunized monkeys. The antibodies were cold and warm saline agglutinins, hemolysins, and Coombs reactive agglutinins. Three distinct cold reactive saline agglutinins were isolated. The antigens of parents and infants followed the rules of Mendelian inheritance according to their specific reactions to the three monospecific sera produced. Patterns of first generation inheritance were established and plans for second generation breeding were able to be made in order to produce animals with as few different antigens as possible. This information should greatly facilitate the study of the blood groups of Macaca irus monkeys. (Author)