Experimentelle Untersuchungen ueber den Wirkungsmechanismus von Raubasin (Lamuran (trade mark)) (Investigations on Raubasin (Lamuran (trade mark)): The Effects on the Veins).

摘要

The effects of Raubasin (Lamuran) on the peripheral venous tone, the central venous pressure, the peripheral blood flow, the heart rate and the arterial blood pressure have been studied in 8 volunteers in the prone position in order to ellucidate the mode of action of this drug. Raubasin was administered intravenously 2 times 20 mg Raubasin in an interval of 20 min. In these experiments there was no evidence for the primary venoconstrictive effect of Raubasin as described by other authors. Neither the coefficient of volume elasticity of the forearm nor the central venous pressure showed any significant changes during administration of Raubasin. Only a short lasting elevation of the peripheral venous pressure during administration of Raubasin was observed, which was preceded by a decrease of the peripheral arteriolar resistance. It is concluded that the increase of the peripheral venous pressure during administration of Raubasin is not due to venoconstriction but due to a short lasting increase of peripheral blood flow. (Modified author abstract)