Improvements in Diagnostic Accuracy with Quantitative Dynamic Contrast- Enhanced MRI.

摘要

We developed novel calibration phantoms that when placed in a breast coil during a routine dynamic contrast enhanced MRI of the breast allow for the acquisition of quantitative images displaying the concentration of contrast media as well as MRI-detectable proton density. To date 21 patients have been scanned with the phantoms. Preliminary results suggest a differentiation between benign and malignant lesion by peak concentration of contrast media. A study is under way to determine whether these methods eliminate any variability seen across two different field strengths, 1.5T and 3T. These methods also allow for pharmacokinetic modeling, which will lead to physiological parameters that have been shown to be diagnostically useful.