Utility of Serum Protein-Bound Neutral Hexoses and L-Focose for Estimation of Malignant Tumor Extension and Evaluation of Efficacy of Therapy.

摘要

A method is employed which permits correction for the influence of the neutral hexoses galactose and mannose on the apparent concentration of protein-bound L-fucose as estimated by the Dische-Shettles CyR3 reaction. The values thus obtained, together with the serum concentrations of neutral hexoses, were evaluated in a series of patients, 109 of whom had confirmed diagnoses of cancer. While these two parameters, protein-bound neutral hexoses and protein-bound fucose, were not by themselves sufficient for differential diagnostic application, excellent correlation for presurgical estimation of tumor extension or activity and postsurgical evaluation of efficacy of treatment was achieved. (Author)