Pharmacokinetic Rationale for a Malarial Suppressant Administered once Monthly.

摘要

Serum was collected from six adults participating in a field trial of sulfadoxine and pyrimethamine in combination which was being administered once monthly for malaria suppression. Samples were drawn during each of two consecutive months three hours, and 7, 14 and 28 days following a dose of 1 500 mg sulfadoxine and serum sulfadoxine concentration was measured. Initial serum concentrations averaged 19.9 + or - 2.4 (SD) mg/100 ml and decayed to 6.2 + or - 2.8 mg/100 ml at 14 days. Serum sulfadoxine concentrations were still detectable at 28 days following a dose (2.1 + or - 1.5 mg/100 ml). Elimination half-time averaged 195 + or - 44 hours. The persistent serum concentrations of sulfadoxine following monthly doses during field-use of this drug are in agreement with successful clinical results previously reported.