Effect of KCl Infusion on Renin Secretory Rates and Aldosterone Excretion in Dogs.

摘要

The effects of unilateral intrarenal arterial KCl infusion in dogs (12 ueq/kg/per min) on bilateral renal function, renin secretory rates, and aldosterone excretion were studied. During KCl infusion, infused-side renal arterial plasma (K+) increased by 2.2 + or - 0.6 meq/liter. Systemic plasma (K+) simultaneously rose by 0.6 + or - 0.1 meq/Liter. Plasma renin activity decreased 29 + or - 9%, and the decrease correlated with the increases in plasma greater in each experiment on the infused side. Aldosterone excretion increased during KCl infusion by 72 + or- 17%, despite a bilateral increase in K+ excretion, and a positive correlation was observed between the net alterations in K+ and Na+ excretion. No significant alterations in systemic blood pressure, glomerular filtration rate, total renal blood flow, or intracortical renal blood flow distribution were observed. These studies suggest that K+ inhibits the release of renin by an intrarenal mechanism, which may be related to a K+ induced alteration in Na+ absorption. (Author)