New Aspects of Analytical and Clinical Toxicology.

摘要

Female rats were made tolerant to and possibly dependent upon methadone by seven weeks of continuous subcutaneous injections twice daily. Distinct abstinence signs were observed. Withdrawal was monitored by assessing 'wet-dog' shakes, a procedure used to quantitate morphine dependence in rats. The data imply that wet-dog shakes may constitute a satisfactory index for determining methadone dependence in this species. (Author)