Synthesis of Substituted Piperazines and Related Compounds as Antimalarials.

摘要

The report presents research on the preparation oof 1-(p-methoxycinnamoyl)-4-(5-phenyl-4-oxo-2-oxazolin-2-yl) piperazine. Seventy-one compounds were prepared. The compounds which showed antimalarial activity against P. berghei in mice or P. gallinaceum in chicks are listed. The methods used to prepare the compounds are described. The most active compound, 1,4-methoxy-cinnamoyl-4-(5-p-chlorophenyl-4-oxo-2-oxazolin-2- yl)piperazine, RMS-17 (BB 45785) is as active as the lead compound RM-682 (AX 88991).