Klinefelter's Syndrome: Examination of Thyroid Function and the TSH and PRL Responses to Thyrotropin-Releasing Hormone Prior to and after Testosterone Administration.

摘要

Thyroid function and prolactin (PRL) responsiveness to thyrotropin-releasing hormone (TRH) were examined in 6 patients with Klinefelter's syndrome prior to and after therapy with testosterone. The thyroid function tests were normal during both periods of study. Testosterone treatment had no significant effect on any of these parameters with the exception of the Resin T(3) Uptake which increased. PRL responses to TRH were significantly higher than those observed in normal men. Despite the fact that mean plasma PRL responses to TRH were decreased when the patients were restudied during testosterone therapy, they remained greater than those of normal men. Mean serum estradiol concentrations were normal and did not increase significantly during testosterone therapy.