The Acute and Chronic Biochemical and Behavioral Effects of Cyclotrimethylenetrinitramine.

摘要

The overall objective of this project was to determine if trimethylenetrinitramine, a central excitatory agent, induces changes in behavior, in brain metabolism and in neurotransmitters. This objective was approached through a comparison of doses and time relationships between changes in biochemical parameters and changes in behavioral measures of brain activity. This report presents the results of studies designed to (1) Establish the effect of trimethylenetrinitramine on oxygen uptake and determine the effect on two specific brain enzyme systems, brain cholinesterase and monoamine oxidase. (2) Establish the effect of trimethylenetrinitramine on steady state levels and turnover rates of brain norepinephrine, dopamine, 5-hydroxytryptamine and possible gama-aminobutyric acid (GABA).