Interactions of the Antibiotic Distamycin A with Homopolymeric Single-Stranded Polydeoxyribonucleotides and with Phi X 174 Deoxyribonucleic Acid.

摘要

The absorption spectrum of distamycin A was changed by poly dA, poly dT, poly dG and poly dC and also phi X 174 DNA. Poly dA and, to a lesser extent, poly dG induced a cotton effect in the ORD spectrum of distamycin A. The complex of distamycin A and Phi X 174 DNA showed a reversible cooperative transition upon heating and cooling. Distamycin a inhibited the template activities of poly dA and poly dT in an RNA polymerase reaction in vitro. (Author)