Toxicological Basis for Controlling Levels of Mustard in the Environment.

摘要

Very little quantitative information exists on the toxicological effects of repeated exposures to small doses or low concentrations of mustard (HD). Such data are required to verify the adequacy of controls to prevent hazards to handlers and to the general population. The effects of repeated exposures to HD vapors in dogs,rabbits,guinea pigs,rats,and mice were studied. The variety of observations made included general toxicity,skin and eye effects,blood chemistry,sensitization,mutagenesis,teratogenesis,carcinogenicity,and other pathological effects. Based on the data accumulated,control limits and ceiling values are proposed. A control limit is the maximum average airborne concentration of a substance to which it is believed that essentially all members of a specified population can be exposed for a specified period without adverse effects.