Characterizing the Relationship Between Blast Exposure and Mild TBI with Dynamic Modeling and Testing in a New Mouse Model

摘要

The purpose of this research is to determine through analytical modeling and animal-based experiments the blast-level threshold for mild traumatic brain injury in humans. We have cataloged brain material properties and determined microtubule geometry and response to mechanical loading. Basic axon geometry has been determined for a finite element (FE) model and modified geometry has also been developed. Blast pressure profiles for small IED and other blast scenarios have been determined from literature reviews. Preliminary models and test fixtures have been constructed. In a tandem effort, laboratorybased animal experiments are being conducted to determine the effects of impact-induced or blast-induced mTBI on loss of consciousness, vestibular motor ability, learning and memory, anxiety, depression, insomnia, and compulsive behaviors. Also, evaluation as to the brain regions with diffuse axonal injury or myelin damage is being conducted. In summary, FE modeling of axon geometry and related blast profiles for models are being completed and will be related to laboratory-based experimentation.