A Screening Procedure with Sporozoite-Induced 'Plasmodium berghei' Infections in Mice, Based on the Mortality of Negative Controls.

摘要

This feasibility study has produced a sporozoite-induced rodent malaria test system that is based on the mortality rather than on the morbidity of negative controls. The test is performed with the NK65 strain of Plasmodium berghei, Anopheles stephensi and ICR/Ha Swiss mice. Although the test may be used to determine or confirm antimalarial activity, it is intended to serve as a primary screening procedure that will provide quantitative evaluations of classes of chemical compounds indicating prophylactic usefulness in P. berghei infections.