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Inhibition of Cyclic Adenosine 3',5'-Monophosphate-Dependent Protein Kinase by Chlorpromazine.

机译：氯丙嗪对环腺苷3'，5'-单磷酸依赖性蛋白激酶的抑制作用。

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Chlorpromazine (CPZ) protects rabbits against anticholinesterase poisoning, while cyclic adenosine 3',5'-monophosphate (cAMP) potentiates the toxicity of anticholinesterase compounds. Chlorpromazine is shown to be a noncompetitive inhibitor of cAMP activation of cAMP-dependent protein kinase (PK). The metabolic and pharmacological consequences of CPZ inhibition of PK and its possible relationship to protection against anticholinesterase agents are discussed.

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作者
Maxwell, D. M.;
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年度 1975
页码 1-10
总页数 10
原文格式 PDF
正文语种 eng
中图分类工业技术;
关键词
Chlorpromazine; Cholinesterase inhibitors; Enzymes; Metabolism; Pharmacology; Phenothiazines; Therapy; Prophylaxis; Lethal agents; Chemical agents; Inhibition; Rabbits; Laboratory animals; Experimental data; Toxicology; Poisoning; Adenylic acids; Kinases;

机译：氯丙嗪;胆碱酯酶抑制剂;酶;代谢;药理学;吩噻嗪;治疗;预防;致死剂;化学药剂;抑制;兔;实验动物;实验数据;毒理学;中毒;腺苷酸;激酶;

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1. Adenosine 3′:5′-cyclic monophosphate-dependent protein kinase in brown fat from newborn rabbits. Changes in the binding of adenosine 3′:5′-cyclic monophosphate after preincubation of the tissue with noradrenaline or incubation of the enzyme with adenosine triphosphate [J] . B L Knight The biochemical journal . 1975,第3期

机译：新生兔褐色脂肪中的腺苷3'：5'-环一磷酸依赖蛋白激酶。用去甲肾上腺素预孵育组织或将酶与三磷酸腺苷孵育后，腺苷3'：5'-环一磷酸结合的变化
2. Adenosine 3′:5′-cyclic monophosphate-dependent protein kinase(s) of rat ovarian cells. Gonadotropin regulation of adenosine 3′:5′-cyclic monophosphate-receptor activity [J] . K. M. Jairam Menon, Salman Azhar The biochemical journal . 1978,第3期

机译：大鼠卵巢细胞的腺苷3'：5'-环一磷酸依赖蛋白激酶。促性腺激素调节腺苷3'：5'-环一磷酸受体活性
3. Effects of cyclic adenosine monophosphate-dependent protein kinase and calcium-dependent protein kinase modulators on stimulated gastric acid secretion in the perfused rat stomach. [J] . Rotker JD, Strapko A, Nandi J, Pharmacology: International Journal of Experimental and Clinical Pharmacology . 1995,第4期

机译：环腺苷一磷酸依赖性蛋白激酶和钙依赖性蛋白激酶调节剂对大鼠灌胃胃酸分泌的影响。
4. Adenosine monophosphate-activated protein kinase status modulates kinetics of post-mortem pH decline and meat quality in pig Longissimus muscle [C] . Faure J., Lebret B., Ecolan P., ICoMST 2011;International conference of meat science and technology . 2012

机译：腺苷一磷酸激活的蛋白激酶状态调节猪Longissimus肌肉的死后pH下降和肉质动力学
5. INTERRELATIONSHIPS BETWEEN PROSTAGLANDINS, CYCLIC ADENOSINE 3',5'-MONOPHOSPHATE AND NUCLEAR PROTEIN PHOSPHORYLATION DURING INDUCED REGRESSION IN RAT MAMMARY TUMORS (CYCLIC-AMP). [D] . FOECKING, MARY KATHERINE. 1982

机译：大鼠乳腺肿瘤引起的衰老过程中前列腺素，循环腺嘌呤3'，5'-单磷酸盐和核蛋白磷酸化的相互关系。
6. Adenosine 3:5-cyclic monophosphate-dependent protein kinase in brown fat from newborn rabbits. Changes in the binding of adenosine 3:5-cyclic monophosphate after preincubation of the tissue with noradrenaline or incubation of the enzyme with adenosine triphosphate. [O] . B L Knight 1975

机译：新生兔棕色脂肪中的腺苷3：5-环一磷酸依赖蛋白激酶。用去甲肾上腺素对组织进行预温育或将酶与三磷酸腺苷温育后腺苷3：5-环一磷酸结合的变化。
7. Adenosine 3':5'-cyclic monophosphate-dependent protein kinase in brown fat from newborn rabbits. Changes in the binding of adenosine 3':5'-cyclic monophosphate after preincubation of the tissue with noradrenaline or incubation of the enzyme with adenosine triphosphate. [O] . Knight, B L 1975

机译：新生兔棕色脂肪中的腺苷3'：5'-环一磷酸依赖蛋白激酶。用去甲肾上腺素对组织进行预温育或将酶与三磷酸腺苷温育后，腺苷3'：5'-环一磷酸结合的变化。

Inhibition of Cyclic Adenosine 3',5'-Monophosphate-Dependent Protein Kinase by Chlorpromazine.

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