Acute Systemic Toxicity of Pure Dimercaprol and Trimercaptopropane.

摘要

The presence of 1,2,3-trimercaptopropane in dimercaprol (2,3-dimercapto-1-propanol, British anti-lewisite) is the cause of significant variations in reported toxicity values of dimercaprol. When injected intramuscularly in rats and mice, trimercaptone-free dimercaprol is approximately one-fifth as toxic as toxic as an equivalent amount of trimercaptopropane. No synergistic effects between the two compounds were found.