Preliminary Assessment of Relative Toxicity of Candidate Repellent n-Butylsulfonimidocyclohexamethylene.

摘要

Preliminary assessment of the relative toxicity of a proposed insect repellent n-butylsulfonimidocyclohexamethylene was conducted using laboratory animals. Technical grade compound produced mild primary irritation of the intact and abraded skin of rabbits. Techncial grade compound did not cause eye irritation. Data obtained from 21 days of daily application of 1 percent ethanol solutions to rabbit skin and skin sensitization studies in guinea pigs failed to indicate an unusual degree of hazard associated with its use as a topical repellent. Studies of percutaneous penetration using C(14)-ring labeled compound indicated that this material is readily absorbed through the skin of rabbits. Teratological studies showed that intraperitoneal administration of a high dose (LD50 level) of the compound was embryotoxic while administration of one-fifth the LD50 dose was not embryotoxic.