Extracellular Distribution and Loss of Intravenously Injected Sucrose in the Dog.

摘要

Following intravenous injection in mongrel dogs, sucrose concentrations in arterial blood decreased in accordance with two exponential decay functions; the first describes diffusion to the interstital space; the second describes excretion and utilization by all avenues. On the average, the sucrose concentration in thoracic duct lymph equals that of arterial blood 13.4 min. after injection. Kinetic analysis of the plasma decay curves of 8 dogs yielded an average rate constant of 0.0183 + or - 0.0012, a half-life of 37.9 + or - 7.74 min. and a clearance rate of 3.24 + or - .092 ml/min/kg. Kinetic analysis of the lymph decay curve yielded similar values. Extrapolation of these curves to 0 time and subsequent calculation of extracellular space gave an average values of 2.08 + or - 5.9 and 198 + or - 7.8 ml/kg for plasma and lymph data, respectively. Repeat determination in 4 days based on plasma decay showed weekly variation of 10% or less. During the first hour after injection 59% of the injected dose was recovered in the urine and 1.9% in the bile. (Author)