Relative Effectiveness of Neutron and Gamma Radiation of Trypanosomes for Immunizing Mice Against African Trypanosomiasis.

摘要

Immunity against African trypanosomiasis has been produced in rodents, cattle and monkeys by inoculating them with irradiated blood-form trypanosomes. Until now the immunizing inoculations have been prepared by exposing the parasites to low linear energy transfer (LET) radiation such as X-rays and gamma rays. Since high linear energy transfer radiation, e.g. neutrons, has been shown to have greater biological effectiveness for several purposes than low LET radiation, 2 experiments were designed to compare these 2 types of irradiation for use in immunizing mice against Trypanosoma rhodesiense.