Lactic Acid Derived Biodegradable Implant Materials.

摘要

The constant search for better techniques of surgical repair and the origination of new biodegradable implant materials led the U.S. Army Institute of Dental Research (USAIDR) to investigate the application of these materials to surgical defects. These materials (polylactic acid in the L(+) and DL forms (PLA) and polyglycollic acid (PGA) were tested in an extensive sequential program, from simple biocompatibility through a multitude of surgical applications subsequently producing an extensive knowledge of their biologic behavior and surgical application. Experiments demonstrated a new use of this material as a vehicle for bearing pharmacological agents in the tissue site for long term treatment.