Antigenic Differences Between Gonococci Grown in Guinea Pig Skin Chambers and 'in vitro'.

摘要

Efficient diagnostic tests are needed to reduce gonorrhoea. For many bacterial species antigens responsible for virulence revealed in organisms grown in vivo have been produced in vitro and used in diagnostic tests. Hence the objective was to examine gonococci grown in vivo for antigens not yet demonstrated in vitro. In this pilot study (1 year) it was shown that gonococci grown in subcutaneous guinea pig chambers resembled urethral pus organisms and differed from the same strain grown in vitro. In particular, they resisted killing by human serum and phagocytes and showed in gel diffusion one or two antigens not produced by the parent strain in vitro.