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3-Amino-1,2,4-Benzotriazines and Their N-Oxides as Antifolate-Antimalarials.

机译：3-氨基-1,2,4-苯并三嗪及其N-氧化物作为抗叶酸 - 抗疟药。

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摘要

3-Amino-7-arylsulfonyl-1-2-4-benzotriazines, their 1-oxides and 1,4-dioxides were synthesized as analogs of the potent 2-4-diamino-6-substituted quinazoline antifolate-antimalarials and evaluated for antimalarial activity.

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作者
Parish, W. W.; Johnston, W. D.;
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年度 1976
页码 1-49
总页数 49
原文格式 PDF
正文语种 eng
中图分类工业技术;
关键词
Antimalarials; Triazines; Oxides; Chemical derivatives; Synthesis(Chemistry); Aryl radicals; Sulfonyl radicals; Quinazolines; Plasmodium berghei; Dosage; Mice; Molecular structure; Pharmacological antagonists; Antifolate drugs; 3-Amino-1-2-4-Benzotriazines; 1-2-4-Benzotriazines; 1-2-4-Benzotriazine-1-oxides; 1-2-4-Benzotriazine-1-4-dioxides;

机译：抗疟药;三嗪;氧化物;化学衍生物;合成（化学）;芳基;磺酰基;喹唑啉;伯氏疟原虫;剂量;小鼠;分子结构;药理学拮抗剂;抗叶酸药物; 3-氨基-1-2-4-苯并三嗪; 1-2-4-苯并三嗪类; 1-2-4苯并三嗪-1-氧化物; 1-2-4苯并三嗪-1-4二氧化物;

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专利

1. Characterization of Radicals Formed Following Enzymatic Reduction of 3-Substituted Analogues of the Hypoxia-Selective Cytotoxin 3-Amino-1,2,4-Benzotriazine 1,4-Dioxide (Tirapazamine) [J] . Sujata S. Shinde, Andrej Maroz, Michael P. Hay, Journal of the American Chemical Society . 2010,第8期

机译：自由基还原后的缺氧选择性细胞毒素3-氨基-1,2,4-苯三嗪1,4-二氧化物（Tirapazamine）的3-取代类似物形成的自由基的表征
2. N-Phenyl-1,2,4-triazoline-3,5-dione (PTAD) as a Dienophilic Dinitrogen Equivalent: A Simple Synthesis of 3-Amino-1,2,4-benzotriazines from Arylcarbodiimides [J] . Alajarin M, Bonillo B, Marin-Luna M, European journal of organic chemistry . 2010,第4期

机译：N-苯基-1,2,4-三唑啉-3,5-二酮（PTAD）作为亲二氮的等效氮：从芳基碳二亚胺简单合成3-氨基-1,2,4-苯并三嗪
3. Characterization of Radicals Formed Following Enzymatic Reduction of 3-Substituted Analogues of the Hypoxia-Selective Cytotoxin 3-Amino-1,2,4-Benzotriazine 1,4-Dioxide (Tirapazamine) [J] . Sujata S. Shinde†‡ Andrej Maroz† Michael P. Hay‡ Adam V. Patterson‡ William A. Denny‡ and Robert F. Anderson*†‡ Journal of the American Chemical Society . 2010,第8期

机译：自由基还原后的缺氧选择性细胞毒素3-氨基-1,2,4-苯三嗪1,4-二氧化物（Tirapazamine）的3-取代类似物形成的自由基的表征
4. One-Pot Catalytic Epoxidation Reaction of Perfluoro-2-methyl-2-pentene with Tri-n-butylamine N-oxide or N, N-Dimethylcyclohexylamine N-oxide [C] . Min Sha, Renming Pan, Biao Jiang International Conference on Advanced Materials Research . 2013

机译：全氟-2-甲基-2-戊烯与三 - 丁胺N-氧化物的单罐催化环氧化反应或N，N-二甲基环己胺N-氧化物
5. A STUDY OF THE ACIDITY AND COMPLEXING PROPERTIES OF NITRILOTRIACETIC ACID N-OXIDE, ETHYLENE DIAMINETETRAACETIC ACID N,N'-DIOXIDE, DIPICOLINIC ACID N-OXIDE, AND 8-HYDROXYQUINOLINE-5-SULFONIC ACID N-OXIDE IN AQUEOUS SOLUTION. [D] . FREYER, LARRY EUGENE. 1975

机译：水溶液中亚硝基三乙酸N-氧化物，乙烯二胺基乙酸N，N'-二氧化物，双吡啶甲酸N-氧化物和8-羟基喹啉-5-磺酸磺酸的酸及其络合性能的研究。
6. Tertiary amine N-oxides as bioreductive drugs: DACA N-oxide nitracrine N-oxide and AQ4N. [O] . W. R. Wilson, W. A. Denny, S. M. Pullen, 1996

机译：叔胺N-氧化物作为生物还原药物：DACA N-氧化物硝胺N-氧化物和AQ4N。
7. Initiation of DNA Strand Cleavage by 1,2,4-Benzotriazine 1,4-Dioxide Antitumor Agents: Mechanistic Insight from Studies of 3-Methyl-1,2,4-benzotriazine 1,4-Dioxide [O] . Venkatraman Junnotula, Ujjal Sarkar, Sarmistha Sinha, 2008

机译：通过1,2,4-苯并三嗪1,4-二氧化氧化物抗肿瘤剂的DNA链切割的引发：从3-甲基-1,2,4-苯并三嗪1,4-二氧化硫的研究机械洞察力

3-Amino-1,2,4-Benzotriazines and Their N-Oxides as Antifolate-Antimalarials.

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