Modification, by Aspirin and Indomethacin, of the Haemodynamic and Prostaglandin Releasing Effects of 'E. coli' Endotoxin in the Dog.

摘要

Dogs treated with aspirin (10 mg/kg) 45 min before, and 3 h after, an LD50 dose (1 mg/kg) of E. coli endotoxin were alive 72 h later. Although all dogs in both treated groups survived, only those treated with indomethacin were protected against the fall in blood pressure 1-2 min following endotoxin. Endotoxin increased the level of prostaglandin F 2 alpha in both the mixed venous and arterial blood. No increase was observed in the aspirin and indomethacin-treated groups. Aspirin and indomethacin treatment did not modify thrombocytopaenia or blood coagulation parameters following endotoxin.