Changes in Plasma Cold-Insoluble Globulin Concentration During Experimental Rocky Mountain Spotted Fever Infection in Rhesus Monkeys.

摘要

Cold-insoluble globulin (CIG) concentration was measured in plasma obtained serially from Macaca mulatta experimentally infected with Rickettsia rickettsii. CIG concentration was decreased in all severely infected monkeys, in some to values only 15-25% of the concentration measured prior to infection. Decreased CIG concentration correlated with increased fibrin/fibrinogen degradation products in serum and number of rickettsiae in whole blood.