The Use of Aotus trivirgatus and Macaca mulatta as Tools for Studies on Prevention and Therapy of Infections with Plasmodium Falciparum and Plasmodium Vivax.

摘要

Investigations undertaken during this report period included: I. Searches for blood schizonticidal drugs effective against multidrug-resistant (especially chloroquine-resistant) strains of Plasmodium falciparum - pursued in owl monkeys infected with trophozoites of these strains. II. Searches for tissue schizoniticidal drugs more effective and better tolerated than primaquine, and for companion drugs that would enhance the activities of primaquine without increasing toxicity - pursued in rhesus monkeys infected with sporozoites of P. cynomolgi. III. Studies on IND preparations of new agents, essential to use in human volunteers. IV. Miscellaneous studies on absorption and toxicities of promising new compounds. The search for new blood schizonticides uncovered two Mannich bases highly active against infections with multi-drug-resistant strains. The search for tissue schizonticides uncovered twelve 8-aminoquinolines as active or more active than primaquine.