Development of L Phase Varianta of Pathogenic Neisseria and Their Pathogenicity in Experimental Animals.

摘要

This is the final report of epidemiologic observations on Neisseria meningitidis at the University of Chicago Hospitals and Clinics and laboratory studies on N. meningitidis and N. gonorrhoeae. It compares the incidence of transformation to L phase growth by clinical isolates of the two pathogenic Neisseria. Results are described of the ability of meningococcal L phase organisms to stabilize and their pathogenicity for mice by intraperitoneal inoculation. The studies of N. gonorrhoeae include: (a) the correlation between susceptibility to penicillin and the rate of transformation to L phase growth, (b) the plasmid content of four gonococcal isolates, and (c) the nutritional requirements (auxotypes) and penicillin susceptibilities of normal and atypical gonococcal strains. (Author)