Imaging Molecular Signatures of Breast Cancer With X-ray Activated Nano- Phosphors

摘要

The first year of this research program developed the foundation for a new medical imaging modality, now called Radioluminescence Tomography (RLT), which utilizes biologically compatible phosphor nanoparticles to produce images of molecular breast cancer contrasts. The development of this modality is significant to the early detection of breast cancer, and to provide feedback to guide Radiation Therapy, for such breast cancer treatments as Intraoperative Radiation Therapy. The work in Year 1 developed sophisticated modeling imaging techniques to enable this modality; this algorithm enables higher resolution with lower dose to the internal organs. This grant resulted in the full characterization of phosphor nanoparticles (Gd2O2S:Eu, Tb, Pr) for RLT. This research has also successfully aided in the development of a new radioluminescent phosphor, Barium Yttrium Fluoride. This modality was demonstrated in phantoms and a mouse model. As part of the first-year training goals, this grant has provided the opportunity for extensive training in molecular targeting of cancer, molecular imaging modalities, and opportunities to engage physicians to design appropriate tools. As of today, the results of this grant are: 5 journal publications, including 2 first author, with 2 more in preparation; 8 conference abstracts, including 3 first author, and 2 conference presentations; 4 courses taken, including BioE222: Molecular Imaging, Med374: Medical Device Design (taken after the grant was accepted, but before it was funded), the Comprehensive Cancer Research Training Program, and SIE: The Stanford Institute for Entrepreneurs, and mentoring of 1 undergraduate and 1 high school student.