The Angiotensin I Converting Enzyme.

摘要

The angiotensin I converting enzyme (kininase II; peptidyl dipeptidase; EC 3.4. 15.1) has a dual function: it converts angiotensin I to angiotensin II and it inactivates bradykinin. Lung, kidney, guinea pig plasma and testicles are among the richest sources of the enzyme. Vascular endothelial cells and brush border of renal proximal tubular cells contain high concentrations of the enzyme. The availability of synthetic peptide inhibitors was of great help in establishing the function of converting enzyme in normal and pathological conditions. (Author)