Effect of Small-Particle Aerosols of Rimantadine and Ribavirin on Pathophysiologic Changes Associated with Swine Flu in Mice.

摘要

Small-particle aerosols of rimantadine administered continuously beginning 72 h postinfection for 4 days (21 mg/kg/day) and ribavirin administered beginning 6 h postinfection for 80 min daily for 4 days (26 mg/kg/day) were used to treat experimentally induced influenza A/NJ/8/76 H (sub sw) 1N1 infection in adult female mice (Dub:(ICR)). Over a 12-day period following inoculation, mice from each group were studied at random to assess rectal temperature; arterial blood pH, partial pressures of oxygen and carbon dioxide and bicarbonate ion valves; progressive pulmonary pathophysiological changes, and concurrent lung lesions and lung virus titers. Results in treated mice were compared with data from control groups of normal and infected-untreated mice. The influenza infection with A/NJ virus resulted in hypothermia, bronchial pneumonia, and blood gas alterations. Treatment with ribavirin completely prevented these alterations from occurring. Although rimantadine did not prevent all pathophysiological alterations, it resulted in decreased recovery time.