Cell Surface Changes in Transformed Human Lymphocytes. I. Concanavalin A and E-Phytohemagglutinin Induce Unique Changes in Surface Topography.

摘要

Binding studies with six purified plant lectins were used to investigate membrane alterations that occur in lymphocyte transformation. Normal human peripheral blood lymphocyte transformed with E-PHA or con-A generally possessed increased numbers of lectin receptors. When this increase was corrected for the expanded surface area of transformed lymphocytes, it appeared that E-PHA and con-A each produced a unique and complex reorganization of cell surface topography.