Affinity Column Chromatography on the Enzyme Dihydropteroate Synthetase from Gonococcal Extract and Development of New Chemotherapeutic Sulfur Drugs (Purification of Enzyme Dihydropteroate Synthetase Included).

摘要

The purpose of this work is to provide a rational chemotherapeutic approach to disease of bacterial origin. It focuses on gonorrhea and meningitis but has wider applicability. The methodology involves molecular considerations and therefore requires highly purified enzymes that are responsible for folic acid biosynthesis, and the synthesis and biological evaluations in cell-free systems as well as in vitro of new and complex sulfur containing drugs.