Effect of Staphylococcal Enterotoxin B (SEB) on Cardiorenal Functions in Rhesus Monkeys.

摘要

Selected cardiovascular and renal functions were measured for 5 h in female rhesus monkeys after intravenous (iv) (0.05 and 1.0 mg/kg) or oral (1.0 mg/kg) administration of staphylococcal enterotoxin B (SEB). Cardiovascular functions, renal hemodynamics, and renal metabolism were also studied between 6 and 11 h after iv SEB inoculation. Oral SEB produced few changes in cardiorenal functions. In contrast, iv SEB produced hypotension, tachycardia, increased total peripheral and renal vascular resistance, and decreased cardiac and renal functions. The early significant renal depression was not associated with hypotension (mean arterial blood pressure >100 mm Hg). However, all measured renal functions (except extraction ratio of PAH) were positively correlated with decreased blood pressure (r = 0.52 - 0.71) in the later phase of SEB toxemia. It is concluded that the kidney is one of the organs affected by iv SEB. Renal impairment may partially contribute to death during SEB enterotoxemia in monkeys.