Determination of N,N'-Trimethylene-Bis(Pyridinium-4-Aldoxime) Dibromide by Ion-Pair High-Performance Liquid Chromatography.

摘要

In view of this extensive documentation supporting the therapeutic values of TMB-4, few reports have been published dealing with the analytical quantification of TMB-4 and some of its degradative by-products by more specific methods. Current methodology utilizes colorimetric and spectrophotometric techniques. In many cases, the procedures are tedious and time consuming. In this paper, a relatively simple and specific analytical method for quantifying TMB-4 and some of its degradative by-products by ion-pair high-performance liquid chromatography (HPLC) is described.