Effects of Starvation and Streptococcus Pneumoniae Infection on Carnitine Acylation States in the Rat.

摘要

This study was performed to determine if alterations in carnitine and its acylation states could account for the decreased ketone body production seen during Streptococcus pneumoniae infection in the rat. Despite a lower ketogenic capacity, the hepatic total and free carnitine increases to the same extent in infected rats as in starved control rats. However, variations are seen in the short- and long-chain acylcarnitines of the infected rat. Liver short-chain derivatives were inversely proportional to plasma beta-hydroxybutyrate in fed, starved and infected rats. (Author)